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The strongestdata points against a simple noradrenergic (NE)/seroto-nergic (5-HT) defi ciency hypothesis are: (1) the failure ofnorepinephrine or serotonin synthesis inhibition to createdepressive symptoms in normal individuals, even thoughit can diminish mood in recently depressed individuals(Delgado et al., 1990); and (2) the lack of rapid ameliora-tion of depression following the rapid onset of reuptakeinhibition of various noradrenergic and serotonergic anti-depressant drugs, resulting in significantly more synapticavailability of biogenic amines in forebrain areas withinhours of ingestion (Delgado, 2000, 2004). Hypotheses such as this were at least partially substantiated byreports from Hong Kong, which showed that the death rate among thoseyounger than fifty-five was 3.6 percent, while 18.9 percent of those agedsixty-five to seventy-five and 28.6 percent of those older than seventy-fivesuccumbed (Vedantam and Stein 2003).
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Althoughsome controversy exists as to whether p63 is the targeted gene driving ampli? ca-tion of this locus, several groups have reported increased p63 mRNA levels thatcorrelate with an increase in p63 gene copy number in squamous cell carcinomasof the lung, head, and neck (HNSCCs) [ 84 , 89 , 90]. A spontaneous perforation was observed in the region of theformer tooth 34. Healthy adults can discriminate very subtleaspects of facial features and expressions Healthy adults can discriminate very subtleaspects of facial features and expressions.